Evidence supporting the use of: Polyphenol (unspecified)
For the body system: Prostate

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols are a broad class of plant-derived compounds known for their antioxidant and anti-inflammatory properties. Scientific interest has grown regarding their potential to support prostate health, particularly in the context of benign prostatic hyperplasia (BPH) and prostate cancer prevention. Several epidemiological studies suggest that diets rich in polyphenols—such as those containing green tea catechins, resveratrol (from grapes), and isoflavones (from soy)—may be associated with a lower risk of prostate cancer and improved urinary symptoms related to prostate enlargement. In vitro and animal studies have shown that certain polyphenols can modulate androgen receptor activity, inhibit proliferation of prostate cancer cells, and reduce inflammation, all of which are relevant to prostate health. Limited clinical trials, especially with green tea polyphenols, indicate potential benefits in reducing prostate-specific antigen (PSA) levels and slowing the progression of prostate lesions. However, the evidence is not uniformly strong, especially for unspecified or generic "polyphenol" preparations, as most clinical data focus on specific compounds or extracts. The heterogeneity of polyphenols and differences in bioavailability also complicate drawing firm conclusions. Overall, while there is a plausible scientific rationale and some supportive human data, more rigorous, large-scale clinical trials are needed to establish clear efficacy for polyphenols (unspecified) in supporting prostate health.

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