Evidence supporting the use of: Selenomethionine
For the body system: Prostate

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenomethionine, an organic form of selenium, is used to support prostate health primarily because of selenium’s role as an essential trace mineral with antioxidant properties. Scientific evidence for its use in prostate health is mixed but notable. Several observational studies have suggested that higher selenium status may be associated with a reduced risk of prostate cancer, likely due to selenium’s involvement in antioxidant enzymes (such as glutathione peroxidase) that protect cells from oxidative damage, a process implicated in cancer development. For example, some epidemiological studies have shown an inverse relationship between selenium levels and prostate cancer risk. However, large randomized controlled trials, such as the Selenium and Vitamin E Cancer Prevention Trial (SELECT), did not find a significant reduction in prostate cancer risk with selenium supplementation (as selenomethionine). In some cases, supplementation showed no benefit or even potential harm if selenium status was already adequate. Thus, while the biological rationale for selenium’s role in prostate health is sound, and some population data are supportive, high-quality clinical evidence for selenomethionine supplementation specifically reducing prostate disease risk is limited. Overall, selenomethionine is sometimes included in prostate health supplements, but its use should be guided by individual selenium status and under professional supervision. Over-supplementation should be avoided due to potential toxicity.

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