Evidence supporting the use of: Aspergillopepsin
For the health condition: Protein Digestion (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Aspergillopepsin is a proteolytic enzyme derived from the fungus Aspergillus niger or Aspergillus oryzae. It is used in some dietary supplements to aid protein digestion, particularly in individuals with poor protein digestion or insufficiency of gastric pepsin. The scientific basis for its use stems from its biochemical properties: aspergillopepsin is an acid protease with broad substrate specificity, capable of hydrolyzing a variety of dietary proteins in acidic environments similar to those found in the stomach.

Several in vitro studies have demonstrated that aspergillopepsin effectively breaks down proteins such as casein and gluten under simulated gastric conditions (pH 2-4). For example, research has shown that aspergillopepsin, alone or in combination with other fungal enzymes, can degrade gluten peptides that are resistant to human digestive enzymes. This has led to interest in its use as a digestive aid, especially for people with digestive complaints or those requiring gluten degradation.

However, clinical evidence in humans is limited. Most data come from laboratory studies or animal models, and there are few robust clinical trials evaluating its efficacy in improving protein digestion in humans. Regulatory bodies like the FDA recognize aspergillopepsin as Generally Recognized as Safe (GRAS) for use in food processing, but this does not equate to clinical proof of benefit. Thus, while a scientific rationale exists, the level of evidence supporting its use for poor protein digestion is moderate and largely preclinical.

More about Aspergillopepsin
More about Protein Digestion (poor)

Other health conditions supported by Aspergillopepsin

Digestion (poor)
Protein Digestion (poor)

Products containing Aspergillopepsin

We currently have no products on Vitabase that contain this ingredient.