Evidence supporting the use of: Aspergillus oryzae
For the health condition: Protein Digestion (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Aspergillus oryzae is a filamentous fungus widely used in East Asian food fermentations and is a common source of industrial enzymes, including proteases. Its use for supporting protein digestion is primarily based on its ability to produce proteolytic enzymes that break down proteins into peptides and amino acids. These enzymes, especially Aspergillus oryzae protease, are included in many commercial digestive enzyme supplements intended to aid those with poor protein digestion.

Scientific studies support the general capability of Aspergillus oryzae-derived proteases to hydrolyze dietary proteins efficiently under a range of pH conditions, including those found in the human digestive tract. Several in vitro and animal studies have demonstrated that these enzymes can improve protein breakdown and increase peptide availability. Additionally, a small number of human studies and clinical reports suggest that supplementation with fungal proteases, including those from A. oryzae, may alleviate symptoms like indigestion and bloating associated with poor protein digestion.

However, high-quality, large-scale clinical trials specifically investigating the effects of A. oryzae proteases on protein digestion in humans are limited. Most evidence is from laboratory or pilot human studies. Based on this, the evidence for Aspergillus oryzae's use in supporting protein digestion is rated as moderate (3/5), with scientific validation primarily derived from biochemical studies and limited clinical data.

More about Aspergillus oryzae
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