Evidence supporting the use of: Bile acid (unspecified)
For the health condition: Protein Digestion (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bile acids are scientifically recognized for their role in the digestion and absorption of dietary fats and fat-soluble vitamins, but they also play an indirect role in protein digestion. Bile acids themselves do not directly break down proteins; rather, they emulsify dietary fats, facilitating the action of pancreatic enzymes, including proteases. In cases of biliary insufficiency (such as after gallbladder removal or in certain liver diseases), supplementation with bile acids (e.g., ox bile) may help restore normal digestion, primarily of fats but with some potential benefit for overall digestive efficiency, including protein digestion by promoting optimal pH and enzyme activity in the small intestine.

Clinical evidence specifically supporting bile acid supplementation for poor protein digestion is limited, but there is a plausible physiological basis. Some small studies and case reports suggest improved digestive symptoms in patients with pancreatic insufficiency or post-cholecystectomy when given bile acid supplements, though these improvements are mostly related to fat malabsorption. No large randomized controlled trials have demonstrated direct benefits for protein digestion alone. Thus, while there is scientific rationale and clinical use in specific digestive disorders, the evidence is moderate and largely extrapolated from bile acids' general role in digestion rather than direct effects on protein breakdown.

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