Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Exo-peptidases are enzymes that catalyze the cleavage of terminal amino acids from the ends of peptide chains, thereby assisting in the final stages of protein digestion. There is moderate scientific evidence supporting the use of exo-peptidases to aid individuals with poor protein digestion, especially when there is a deficiency of endogenous digestive enzymes (such as in pancreatic insufficiency or some GI disorders). Scientific studies have demonstrated that exogenous supplementation with digestive enzymes, including peptidases, can improve the breakdown and absorption of dietary proteins, reducing symptoms such as bloating, flatulence, and protein malabsorption.

Clinical trials and in vitro studies have shown that enzyme preparations containing exo-peptidases can increase the rate and extent of protein hydrolysis. In patients with medical conditions that impair normal enzyme production (e.g., chronic pancreatitis, cystic fibrosis), supplemental proteases, including exo-peptidases, are used as part of pancreatic enzyme replacement therapy (PERT) and have been shown to improve nutritional status and digestive symptoms.

While the bulk of evidence focuses on individuals with diagnosed enzyme deficiencies, there is less direct evidence supporting use in the general population with only mild or subjective symptoms of "poor" protein digestion. However, the mechanistic rationale and demonstrated efficacy in clinical deficiency states provide a reasonable scientific basis for their use in supporting protein digestion when endogenous enzyme production is compromised.

More about exo-peptidase
More about Protein Digestion (poor)

Other ingredients used for Protein Digestion (poor)

Other health conditions supported by exo-peptidase

Products containing exo-peptidase

Designs For Health AllerGzyme™
Designs For Health Carb-Lipo Control™