Evidence supporting the use of: Alpha Hydroxy Acids
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha Hydroxy Acids (AHAs), such as glycolic acid and lactic acid, are used in dermatology primarily as exfoliants. Their use in psoriasis is supported by some scientific evidence, though not robust. AHAs help to remove the outer layer of dead skin and reduce scaling, which is a hallmark of psoriasis plaques.

Several small clinical studies and case reports have shown that topical application of AHAs can improve the appearance and texture of psoriatic plaques, especially when used as an adjunct to other therapies. For example, glycolic acid has been studied in concentrations ranging from 5% to 15%, demonstrating some ability to decrease scaling and plaque thickness. AHAs work by breaking down desmosomes in the stratum corneum, facilitating desquamation and improving skin smoothness.

However, the evidence base is limited, with most studies being small and lacking rigorous controls. AHAs are not considered a primary or standalone therapy for psoriasis and are more commonly used to enhance the penetration and effectiveness of other topical agents, such as corticosteroids or vitamin D analogues. There is also a risk of irritation or burning, particularly when applied to inflamed or fissured skin.

In summary, while there is some scientific rationale and limited clinical evidence supporting the adjunctive use of AHAs in managing psoriasis symptoms, they are not a mainstay treatment. Their role remains supportive, primarily to improve scale removal and skin texture.

More about Alpha Hydroxy Acids
More about Psoriasis

Products containing Alpha Hydroxy Acids

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