Evidence supporting the use of: Alpha-linolenic acid (ALA)
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-linolenic acid (ALA) is an omega-3 polyunsaturated fatty acid found mainly in plant sources such as flaxseed, chia, and walnuts. Its use in the context of psoriasis is based on the scientific understanding that omega-3 fatty acids possess anti-inflammatory properties, which may be beneficial in managing inflammatory conditions such as psoriasis. Several studies have investigated the effects of omega-3 fatty acids (including ALA, as well as eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA], which are primarily found in fish oil) on psoriasis. While most clinical evidence is stronger for EPA and DHA, ALA is thought to contribute by serving as a precursor to these longer-chain omega-3s, albeit with limited conversion efficiency in humans.

A few small clinical trials and observational studies have suggested that diets high in ALA or supplementation with ALA-rich oils may result in mild improvements in psoriatic symptoms, likely through modulation of inflammatory pathways. However, the evidence is not robust: systematic reviews and meta-analyses generally conclude that while omega-3 supplementation may have a modest benefit, the specific effect of ALA (as opposed to fish-derived omega-3s) is less well established. There are plausible mechanisms—such as decreased production of pro-inflammatory cytokines—but the direct clinical impact of ALA is not confirmed by large, high-quality trials.

In summary, while there is a scientific rationale and some limited evidence supporting the use of ALA for psoriasis, the overall quality and quantity of evidence is low, and ALA should not be considered a primary treatment. It may be used as an adjunct to conventional therapy in the context of a healthy diet.

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