Evidence supporting the use of: Apigenin
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a natural flavonoid found in various plants, including parsley, celery, and chamomile. Its use in supporting or treating psoriasis is based on emerging scientific evidence rather than longstanding traditional application. Preclinical studies, primarily conducted in vitro (cell cultures) and in animal models, have demonstrated that apigenin exhibits anti-inflammatory, antioxidant, and immunomodulatory effects, which are relevant to the pathophysiology of psoriasis. For example, research has shown that apigenin can inhibit the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17, which play key roles in the development and progression of psoriatic lesions (Li et al., 2018). Additionally, apigenin has been reported to suppress the activation of NF-κB, a transcription factor involved in inflammation and immune responses. However, there is a lack of robust clinical data in humans directly evaluating apigenin for psoriasis treatment. No large-scale randomized controlled trials have been published to date. The evidence for apigenin’s efficacy in psoriasis is therefore limited to preclinical studies, and more research is needed before it can be recommended as a standard or adjunctive therapy. In summary, while there is a scientific basis for investigating apigenin in psoriasis, current evidence supporting its use is preliminary and not yet sufficient for clinical recommendations.

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Products containing Apigenin

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