Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-glucan is a naturally occurring polysaccharide found in the cell walls of cereals, bacteria, and fungi. Its use in psoriasis is primarily backed by scientific rationale rather than tradition, although the level of evidence is modest. Beta-glucan is recognized for its immunomodulatory and anti-inflammatory properties, which are relevant to the pathogenesis of psoriasis, a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes and immune dysfunction.

Several preclinical studies have demonstrated that beta-glucan can modulate immune responses, including the reduction of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17, all of which play roles in psoriasis. Animal studies and in vitro models have shown that topical or systemic administration of beta-glucan can improve skin barrier function and reduce inflammation. Some small clinical trials and case reports have reported improvement in psoriatic plaques with the topical application of beta-glucan-containing creams, suggesting potential benefits.

However, robust, large-scale, placebo-controlled clinical trials in humans are lacking, and most evidence comes from smaller pilot studies, animal models, or extrapolation from the effects of beta-glucan in other inflammatory or immune-mediated conditions. Therefore, while there is a plausible scientific basis and some early supportive evidence, the overall strength of clinical evidence is limited, justifying a moderate evidence rating. Further research is necessary to conclusively establish beta-glucan’s efficacy and safety for psoriasis treatment.

More about beta-glucan
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