Evidence supporting the use of: Caffeic Acid
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caffeic acid is a naturally occurring polyphenol found in many plants, especially coffee, fruits, and some herbs. Its potential use in supporting or treating psoriasis is based primarily on its anti-inflammatory and antioxidant properties, which have been demonstrated in preclinical (in vitro and animal) studies. Several studies have shown that caffeic acid can inhibit pro-inflammatory cytokines and reduce oxidative stress, both of which play significant roles in the pathogenesis of psoriasis. For example, research published in Biomedicine & Pharmacotherapy (2017) and other journals has reported that caffeic acid and its derivatives can suppress key inflammatory pathways such as NF-κB and decrease the production of cytokines like TNF-α, IL-1β, and IL-6. However, there are no robust clinical trials in humans specifically evaluating caffeic acid for the treatment or support of psoriasis. The evidence is thus limited to laboratory and animal studies, and while promising, does not yet support its use as a standard therapy. There is no substantial record of traditional use of caffeic acid specifically for psoriasis, though it is present in many traditionally used medicinal plants. Overall, the evidence base is still preliminary and further research, especially human clinical trials, is needed to confirm its efficacy and safety for psoriasis management.

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