Centella triterpenes, the key active constituents from Centella asiatica (also known as gotu kola), have been explored for their potential in treating inflammatory skin conditions, including psoriasis. The most relevant triterpenes include asiaticoside, madecassoside, asiatic acid, and madecassic acid. Several in vitro and animal studies indicate that these compounds exhibit anti-inflammatory, antioxidant, and wound-healing effects, which could be beneficial in psoriasis—a chronic immune-mediated disease characterized by hyperproliferation and inflammation of the skin.

Specific research has shown that Centella triterpenes can inhibit the release of pro-inflammatory cytokines such as TNF-α and IL-6, both of which play a role in psoriasis pathogenesis. Some studies have also demonstrated improved skin barrier repair and reduced keratinocyte proliferation in models relevant to psoriasis. However, while these mechanisms are promising, clinical evidence in humans is limited. Only a few small-scale clinical studies and case reports have evaluated Centella extracts in psoriasis patients, often in combination with other agents, making it difficult to isolate the effect of Centella triterpenes specifically.

In summary, there is some scientific rationale and preliminary evidence for the use of Centella triterpenes in psoriasis, but high-quality clinical trials are lacking. The evidence is stronger than for many herbal remedies, but not robust enough to warrant broad clinical recommendations.