Cnidium (Cnidium monnieri) is a traditional Chinese medicinal herb that has been used for various skin conditions, including psoriasis, primarily in the context of traditional medicine. Its seeds, known as She Chuang Zi, are often incorporated in topical preparations and herbal formulas to treat itchy skin, eczema, and other dermatological issues. The rationale for its use in psoriasis is based on its reputed antipruritic (anti-itch), anti-inflammatory, and antimicrobial effects observed in traditional practice. However, while Cnidium is well-documented in the Chinese pharmacopeia for general skin health, there is little to no modern clinical research specifically validating its efficacy for psoriasis. Most scientific studies have focused on its bioactive compounds (such as osthole) in vitro or in animal models, demonstrating anti-inflammatory and immunomodulatory potential, but not directly in the context of human psoriasis. Therefore, current support for Cnidium's use in psoriasis management is grounded in traditional use rather than robust scientific evidence or clinical trials.