Evidence supporting the use of: Docosahexaenoic Acid
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Docosahexaenoic Acid (DHA) is an omega-3 polyunsaturated fatty acid primarily found in fish oil. Its use in psoriasis is based on scientific research investigating the anti-inflammatory properties of omega-3 fatty acids, including DHA. Psoriasis is a chronic, immune-mediated skin condition characterized by hyperproliferation of keratinocytes and inflammation. Some clinical studies suggest that omega-3 fatty acids can reduce the severity of psoriasis symptoms, potentially by modulating inflammatory cytokines such as TNF-α, IL-1β, and IL-6, which are implicated in the pathogenesis of psoriasis.

However, most of the evidence comes from studies using mixed omega-3 supplementation (e.g., EPA and DHA together) rather than DHA alone. For example, a 2014 systematic review (Am J Clin Dermatol) found modest benefit for omega-3 supplementation in psoriasis but noted heterogeneity in study design, dosage, and formulations. There is limited direct evidence for DHA as a standalone intervention. Most clinical trials have small sample sizes and short durations, and not all have shown significant clinical improvements.

In summary, while there is some scientific rationale and modest clinical evidence supporting the use of DHA (as part of omega-3 fatty acids) in managing psoriasis, the strength of the evidence is limited. DHA is not considered a primary or stand-alone treatment, and further large, well-controlled studies are needed to clarify its specific role.

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Products containing Docosahexaenoic Acid

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