Evidence supporting the use of: Epigallocatechin
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin, particularly in the form of epigallocatechin-3-gallate (EGCG), is a major polyphenol found in green tea that has been investigated for its potential therapeutic effects in psoriasis. Several preclinical studies, especially in vitro and animal models, have shown that EGCG can modulate immune responses, reduce oxidative stress, and inhibit the proliferation of keratinocytes, which are all relevant mechanisms in the pathophysiology of psoriasis. For example, EGCG has been demonstrated to suppress the expression of inflammatory cytokines such as TNF-α, IL-17, and IL-23, which are elevated in psoriatic lesions. Additionally, some research indicates that topical application of EGCG can reduce the severity of psoriasis-like skin inflammation in mouse models.

However, despite these promising findings in laboratory and animal studies, robust clinical evidence in humans is limited. Only a few small clinical trials and case reports have explored EGCG-containing formulations for psoriasis, and while some have reported mild improvements in symptoms, results are not consistent or definitive. There are no large-scale, placebo-controlled clinical trials validating the efficacy or safety of EGCG as a treatment for psoriasis in humans. As a result, while the scientific rationale exists and early-stage evidence is encouraging, the overall level of evidence supporting the use of epigallocatechin for psoriasis remains preliminary and warrants further investigation.

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