Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG), a major polyphenol found in green tea, has been investigated for its potential benefits in treating psoriasis, a chronic inflammatory skin disorder. The interest in EGCG for psoriasis stems from its well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. Preclinical studies, particularly in vitro and animal models, have shown that EGCG can inhibit the proliferation of keratinocytes (skin cells), reduce the production of inflammatory cytokines (such as TNF-α, IL-6, and IL-17), and modulate pathways involved in psoriatic inflammation (notably NF-κB and STAT3 signaling). Some studies suggest topical EGCG application may reduce the severity of psoriatic lesions in mouse models.

However, clinical evidence in humans is limited. Small pilot studies and case reports indicate that topical formulations containing EGCG may improve psoriatic plaques, but robust randomized controlled trials are lacking. There is also limited data about the efficacy and safety of oral EGCG supplements for psoriasis in humans. While the mechanistic rationale is promising and animal data supports potential benefit, the overall evidence is still preliminary. Thus, EGCG’s use for psoriasis is considered scientifically motivated but not yet strongly validated, meriting a score of 2/5 for evidence strength.

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