Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ferulic acid is a plant-derived phenolic compound with well-documented antioxidant and anti-inflammatory properties. Its use in supporting or treating psoriasis is primarily justified by preliminary scientific studies, rather than traditional medicine. Several in vitro and animal studies have shown that ferulic acid can modulate inflammatory pathways, such as inhibiting the expression of pro-inflammatory cytokines (e.g., TNF-α, IL-6) and reducing oxidative stress, both of which play significant roles in the pathogenesis of psoriasis. For instance, a few experimental studies have demonstrated that topical or oral administration of ferulic acid reduces skin inflammation and inhibits the proliferation of keratinocytes, which are central features of psoriatic lesions.

However, there is a lack of robust clinical trials specifically investigating ferulic acid in human subjects with psoriasis. Most available data are limited to cellular models or animal studies. Some cosmetic and skincare formulations include ferulic acid for its general skin-soothing effects, but its direct efficacy against psoriasis in humans remains unproven. Therefore, while there is a scientific rationale for its potential benefit, the quality and quantity of evidence supporting its use in psoriasis is still preliminary and insufficient for strong recommendations. Further clinical research is needed to confirm its safety and efficacy in this specific condition.

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