Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Research into the use of fish protein for the treatment or support of psoriasis is limited, but there is some scientific rationale and preliminary evidence, mainly related to fish-derived nutrients such as omega-3 fatty acids and certain peptides. Fish proteins, particularly from cold-water fish, are often associated with anti-inflammatory properties due to their content of bioactive peptides and amino acids, as well as their correlation with omega-3 fatty acids (though technically the fats, not the proteins, provide most of the omega-3s). A few small studies and animal models suggest that fish-derived peptides may modulate immune responses and reduce inflammation, which is relevant since psoriasis is an inflammatory, immune-mediated skin disorder. However, most clinical trials and systematic reviews focus on fish oil supplementation (omega-3 fatty acids) rather than on fish protein itself. The evidence for fish protein specifically as a treatment for psoriasis is sparse, and its direct effects remain unclear. Therefore, while there is some scientific interest and plausible mechanisms, the direct evidence is weak and insufficient for strong clinical recommendations. Most benefits attributed to fish in psoriasis are due to the oil rather than the protein fraction. More rigorous studies are needed to establish efficacy and understand the mechanisms involved.

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