Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma Linolenic Acid (GLA) and Psoriasis: Evidence Overview

Gamma linolenic acid (GLA) is an omega-6 fatty acid found in oils such as evening primrose oil, borage oil, and black currant seed oil. Its use in psoriasis is supported by a modest body of scientific research, although results are mixed and generally not robust.

The rationale for using GLA in psoriasis is based on its role in modulating inflammatory pathways. GLA is metabolized into dihomo-γ-linolenic acid (DGLA), which can be converted into anti-inflammatory prostaglandins (PGE1), potentially helping to counteract the chronic inflammation characteristic of psoriasis. GLA may also help maintain skin barrier function, which can be compromised in psoriatic lesions.

Several small clinical trials and open-label studies have explored the effects of GLA supplementation in psoriasis patients. For example, a 1990 study using evening primrose oil (a source of GLA) showed some improvement in skin symptoms in a subset of participants. However, many studies have methodological limitations, such as small sample sizes, lack of placebo control, or short duration. Systematic reviews and meta-analyses generally conclude that evidence for GLA's efficacy in psoriasis is limited and inconclusive (source).

In summary, while there is a scientific basis and some preliminary clinical investigation supporting the use of GLA for psoriasis, high-quality evidence is lacking. GLA is sometimes used as an adjunctive therapy, but it should not replace standard medical treatments.

More about gamma linolenic acid (GLA)
More about Psoriasis

Other ingredients used for Psoriasis

Other health conditions supported by gamma linolenic acid (GLA)

Products containing gamma linolenic acid (GLA)

Vitabase Active Woman's Multi
Pure Encapsulations Black Currant Seed
Pure Encapsulations Black Currant Seed
Vitabase Complete Essential Fatty Acids
Pure Encapsulations EFA Essentials
Designs For Health GLA (Gamma-Linolenic Acid)
Metagenics OmegaGenics Evening Primrose Oil
Metagenics OmegaGenics GLA 240 mg
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Vitabase Super Fat Burner
Douglas Laboratories Ultra G.L.A. Borage Oil
Douglas Laboratories Ultra G.L.A. Borage Oil
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA