Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycyrrhizinic acid, a major active component of licorice root (Glycyrrhiza glabra), has been investigated for its potential role in treating psoriasis. Its use is supported by some scientific evidence, primarily from in vitro and animal studies, although robust clinical trials in humans are limited.

Glycyrrhizinic acid is known for its anti-inflammatory, immunomodulatory, and antioxidant properties. These activities are relevant because psoriasis is a chronic, immune-mediated inflammatory skin disorder. Several laboratory studies have shown that glycyrrhizinic acid can inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-6, which are implicated in the pathogenesis of psoriasis. Additionally, topical formulations containing licorice extracts have demonstrated anti-inflammatory effects in animal models of skin inflammation.

A few small clinical studies and case reports suggest that topical preparations containing glycyrrhizinic acid may help reduce erythema, scaling, and itching in psoriatic lesions. However, these studies often have methodological limitations, such as small sample sizes, lack of control groups, or short follow-up periods. Systematic reviews generally conclude that while the compound shows promise, there is insufficient high-quality evidence to recommend glycyrrhizinic acid as a stand-alone or primary therapy for psoriasis. More rigorous randomized controlled trials are needed to establish efficacy and safety in this indication.

In summary, the use of glycyrrhizinic acid for psoriasis is supported by preliminary scientific evidence, particularly regarding its anti-inflammatory effects, but clinical validation remains limited.

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