Henna (Lawsonia inermis) has a long history of traditional use for treating various skin conditions, including psoriasis, in regions such as the Middle East, North Africa, and South Asia. Folk medicine often relies on henna paste for its cooling, anti-inflammatory, and antimicrobial properties, which are attributed to compounds like lawsone. In traditional practices, henna is applied topically to affected skin to soothe irritation, reduce redness, and provide symptomatic relief.

However, scientific evidence supporting henna's efficacy in treating psoriasis is extremely limited. Most claims are based on anecdotal accounts rather than systematic studies. There are a few in vitro and animal studies suggesting that henna exhibits anti-inflammatory and antioxidant activities, but these findings have not been robustly translated into clinical trials for psoriasis specifically. No large-scale, peer-reviewed clinical trials have been conducted to conclusively validate its use for this condition.

In summary, while henna is used traditionally for psoriasis and may provide some symptomatic relief due to its general skin-soothing properties, the scientific evidence supporting its effectiveness is minimal. Caution is advised, as henna can sometimes cause allergic reactions or worsen symptoms in sensitive individuals.