Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyaluronic acid (HA) is a glycosaminoglycan naturally present in the human skin and connective tissues, renowned for its powerful ability to retain moisture. In the context of psoriasis, topical hyaluronic acid has been explored as a supportive treatment primarily to address xerosis (dryness) and scaling associated with the condition. The scientific rationale rests on its capacity to enhance skin hydration, improve barrier function, and potentially aid wound healing. Several small clinical studies and case reports have shown that topical HA formulations can reduce scaling, itching, and discomfort in psoriatic plaques, especially when used as adjuncts to other therapies like corticosteroids or vitamin D analogues.

Notably, a double-blind, randomized controlled trial published in JEADV (2011) demonstrated that a hyaluronic acid-containing cream led to significant improvement in skin hydration and subjective symptoms in patients with mild-to-moderate psoriasis, compared to placebo. However, the studies are generally small, and few directly compare HA to standard psoriasis treatments. There is limited evidence to suggest that HA possesses anti-inflammatory or immunomodulatory properties that would address the underlying pathogenesis of psoriasis itself. Thus, while HA is scientifically validated as a supportive, symptomatic treatment—particularly for dryness—its direct efficacy against the core mechanisms of psoriasis is unproven. The evidence is considered modest (rated 2/5), and HA should be seen as an adjunctive, not primary, therapy for psoriasis.

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Products containing hyaluronic acid

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Pure Encapsulations Hyaluronic Acid
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Douglas Laboratories Hyaluronic Acid®
Douglas Laboratories Hydrolyzed Collagen+
Pure Encapsulations Joint Complex
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