Evidence supporting the use of: Lactobacillus plantarum
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus plantarum has been investigated in several recent scientific studies for its potential role in managing psoriasis, a chronic inflammatory skin disease. The underlying rationale is based on the gut-skin axis, wherein alterations in the intestinal microbiota are thought to influence systemic inflammation and skin health. Some clinical and preclinical studies suggest that probiotics, including L. plantarum, may help modulate immune responses, reduce inflammatory cytokines, and restore a healthy balance of gut microbiota, potentially benefiting individuals with psoriasis.

For example, a 2021 randomized controlled trial (Frontiers in Immunology, 2021) found that a multi-strain probiotic supplement containing L. plantarum led to modest improvements in psoriasis severity and quality of life compared to placebo. Animal studies also indicate that L. plantarum administration can reduce skin inflammation and modulate immune cell activity relevant to psoriatic pathology. However, these studies often use combinations of probiotic strains, making it difficult to isolate the effects of L. plantarum alone. Furthermore, sample sizes tend to be small, and studies vary in design and outcome measures.

In summary, while there is emerging scientific interest and preliminary evidence supporting the use of L. plantarum-containing probiotics for psoriasis, the strength of this evidence remains limited (rated 2/5). More robust, large-scale clinical trials focusing specifically on L. plantarum as a monotherapy are needed to confirm efficacy and inform clinical recommendations.

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