Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus salivarius has gained interest as a probiotic with potential immunomodulatory and anti-inflammatory effects, which are relevant in the context of psoriasis—a chronic, immune-mediated skin disorder. The rationale for its use is primarily grounded in the growing body of scientific research linking gut microbiome alterations (dysbiosis) to psoriasis pathogenesis. Several studies have observed that people with psoriasis often have a different composition of gut bacteria compared to healthy controls, suggesting that probiotics might help restore microbial balance and modulate systemic inflammation.

Specific research on L. salivarius for psoriasis is limited but emerging. A 2018 pilot study found that a multi-strain probiotic supplement (including L. salivarius) improved clinical outcomes in patients with psoriasis, suggesting a possible benefit. There is also preclinical evidence that L. salivarius can modulate immune responses and reduce inflammation in animal models, which provides biological plausibility for its use.

However, the direct evidence for L. salivarius alone in treating psoriasis is weak (hence, evidence rating 2/5). Most clinical studies use combinations of probiotic strains, making it difficult to attribute effects to this species specifically. Larger, high-quality randomized controlled trials focusing on L. salivarius are needed before strong recommendations can be made. In summary, scientific interest and early clinical data exist, but robust evidence is lacking.

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