Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a flavonoid commonly found in many fruits, vegetables, and medicinal herbs. Its use for psoriasis is primarily supported by preclinical scientific evidence rather than robust clinical trials or traditional use. Several in vitro and animal studies have demonstrated that luteolin possesses anti-inflammatory, antioxidant, and immunomodulatory properties, all of which are relevant to the pathogenesis of psoriasis—a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and infiltration of immune cells.

Research indicates that luteolin can inhibit the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17, which are found to be elevated in psoriatic lesions. For example, a 2019 study published in Phytotherapy Research showed that topical luteolin reduced skin inflammation and thickness in a mouse model of psoriasis. Additionally, luteolin has been observed to suppress the activation of NF-κB and STAT3 signaling pathways, both of which play a pivotal role in the development and persistence of psoriatic plaques.

However, despite these promising findings, there is a lack of high-quality human studies or clinical trials directly assessing luteolin’s effectiveness in treating psoriasis. As such, the evidence is rated as 2 out of 5—suggestive based on preclinical data, but not yet validated in humans. More research, especially well-designed clinical studies, is needed before luteolin can be recommended as a standard treatment for psoriasis.

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