Evidence supporting the use of: Marine fat
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Marine fat, particularly fish oil rich in omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been scientifically investigated for its role in managing psoriasis. Psoriasis is a chronic inflammatory skin condition characterized by hyperproliferation of keratinocytes and an overactive immune response. Omega-3 fatty acids are known to exhibit anti-inflammatory properties, which are believed to help modulate immune system activity and reduce skin inflammation associated with psoriasis.

Several clinical studies and meta-analyses have examined the effect of oral fish oil supplementation in patients with psoriasis. Some randomized controlled trials report modest improvements in erythema, scaling, and pruritus, particularly with high doses of EPA and DHA. The proposed mechanism involves the suppression of pro-inflammatory cytokines and the production of less inflammatory eicosanoids compared to those derived from arachidonic acid (an omega-6 fatty acid). However, the overall quality of evidence is moderate, with some studies failing to show significant benefit, possibly due to variations in dosage, duration, and patient populations.

Topical application of marine oils has less evidence, though some anecdotal and small-scale studies suggest benefits in reducing dryness and irritation. Major dermatological guidelines do not currently recommend fish oil as a primary therapy, but it is sometimes used as an adjunct. In summary, the use of marine fat in psoriasis has scientific backing, but the strength of evidence is moderate (3/5), and more large-scale, high-quality trials are needed.

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