Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oleanolic acid is a naturally occurring triterpenoid compound found in many plants, including olives and medicinal herbs. Its use in psoriasis is primarily supported by preclinical scientific research rather than strong clinical or traditional evidence. Several in vitro and animal studies have demonstrated that oleanolic acid possesses anti-inflammatory, antioxidant, and immunomodulatory activities, which are relevant to the pathogenesis of psoriasis—a chronic, immune-mediated skin disorder characterized by hyperproliferation of keratinocytes and inflammation. Studies have shown that oleanolic acid can inhibit the expression of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17, which are key contributors to the development and maintenance of psoriatic lesions. Additionally, oleanolic acid has been shown to modulate NF-κB and MAPK signaling pathways, both of which play roles in the inflammatory cascade associated with psoriasis.

However, the evidence supporting the use of oleanolic acid in psoriasis is still limited to laboratory (in vitro) and animal (in vivo) models. There is a lack of well-designed human clinical trials to confirm its efficacy and safety in psoriatic patients. Furthermore, oleanolic acid is not a mainstream treatment in traditional medicine specifically for psoriasis, though it is found in plants used for general skin and inflammatory conditions. In summary, while there is scientific rationale and preliminary evidence for its use, clinical validation is lacking, and thus its use remains experimental at this stage.

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