Evidence supporting the use of: Perilla Oil
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Perilla oil, derived from the seeds of Perilla frutescens, is rich in alpha-linolenic acid (ALA), an omega-3 fatty acid known for anti-inflammatory properties. The rationale for its use in supporting psoriasis, a chronic inflammatory skin disorder, is primarily based on the modulation of inflammation via dietary omega-3 fatty acids. Several animal and in vitro studies have demonstrated that perilla oil and its constituents can inhibit pro-inflammatory mediators such as TNF-α and IL-6, both implicated in the pathogenesis of psoriasis. Additionally, perilla oil has demonstrated skin barrier-enhancing effects in some preclinical models.

However, direct clinical evidence in humans supporting the efficacy of perilla oil for psoriasis is limited. Some small pilot studies and case reports suggest that supplementation with omega-3 fatty acids (including ALA) may benefit patients with psoriasis, but most high-quality clinical trials have focused on fish oil (EPA/DHA), not perilla oil specifically. Reviews of the literature generally categorize the evidence as preliminary and insufficient for formal recommendation.

In summary, the scientific basis for perilla oil in psoriasis is supported by mechanistic and preclinical data, with some extrapolation from broader omega-3 fatty acid research, but lacks robust, disease-specific clinical trials. Thus, the evidence is rated as 2 (weak to modest scientific support).

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Products containing Perilla Oil

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