Evidence supporting the use of: Polyphenol (unspecified)
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols, a diverse group of naturally occurring compounds found in plants (such as flavonoids, phenolic acids, stilbenes, and lignans), have garnered scientific interest for their potential role in supporting and treating psoriasis. Psoriasis is a chronic inflammatory skin disorder characterized by overproduction of skin cells and immune system dysregulation. Several laboratory and animal studies have identified that polyphenols possess anti-inflammatory, antioxidant, and immunomodulatory properties. For example, polyphenols like curcumin (from turmeric), resveratrol (from grapes), and epigallocatechin gallate (from green tea) have shown the ability to inhibit pathways involved in psoriasis pathogenesis, such as NF-κB and cytokine signaling.

Some small-scale clinical studies and pilot trials have explored the effects of topical or oral polyphenol-rich extracts in psoriasis patients, reporting improvements in skin lesions, erythema, and scaling. However, these studies often use specific polyphenols rather than “unspecified” polyphenol mixtures, and the sample sizes have generally been small. There is a lack of large-scale, high-quality human trials specifically using “unspecified” polyphenols for psoriasis. Overall, while the biological plausibility and early evidence are promising, the current level of scientific validation supporting the use of generic or unspecified polyphenols for psoriasis is limited and more robust clinical trials are needed.

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