Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has attracted attention for its anti-inflammatory and antioxidant properties. In the context of psoriasis, there is emerging but limited scientific evidence supporting its potential usefulness. Preclinical studies, primarily using animal models and in vitro experiments, have demonstrated that resveratrol can modulate several molecular pathways involved in psoriasis pathogenesis, such as the inhibition of NF-κB activation, reduction of pro-inflammatory cytokines (e.g., TNF-α, IL-17, IL-23), and suppression of keratinocyte hyperproliferation.

A few small-scale studies and experimental models suggest that topical or systemic resveratrol may reduce psoriatic lesion severity by attenuating inflammation and oxidative stress. For example, a 2011 study in mice showed that topical resveratrol reduced epidermal thickness and inflammatory cell infiltration. However, clinical evidence in humans is scarce; there are no large, well-controlled clinical trials to conclusively support its efficacy or safety for psoriasis patients. In addition, the bioavailability of resveratrol when taken orally is relatively low, which may limit its therapeutic potential unless formulated for improved delivery.

Overall, while the mechanistic rationale and preclinical findings are promising, the current level of scientific evidence is limited, and further research—including robust human clinical trials—is needed before resveratrol can be considered a validated treatment option for psoriasis.

More about resveratrol
More about Psoriasis

Other ingredients used for Psoriasis

Other health conditions supported by resveratrol

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