Evidence supporting the use of: Vitamin A (not specified)
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A and its derivatives, known as retinoids, have a well-established scientific basis for use in the treatment of psoriasis. Topical retinoids (such as tazarotene) and systemic retinoids (such as acitretin) are synthetic forms of vitamin A that have been approved and widely used in dermatology for decades. Their efficacy is based on their ability to modulate keratinocyte proliferation and differentiation, as well as their anti-inflammatory effects, which are central to the pathophysiology of psoriasis. Clinical trials and numerous studies have demonstrated that retinoids can significantly improve psoriatic lesions, particularly in cases of plaque-type and pustular psoriasis. However, the use of plain dietary vitamin A (retinol or beta-carotene) is not considered effective or recommended for psoriasis, as the therapeutic concentrations required to affect skin lesions surpass safe dietary levels and pose a risk of toxicity. The scientific validation applies specifically to pharmacological retinoids derived from vitamin A, rather than standard vitamin A supplements. In summary, there is strong scientific evidence supporting the use of vitamin A derivatives (retinoids) in psoriasis management, but not for regular vitamin A supplementation.

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