Vitamin E, particularly in the form of tocopherols (including beta-tocopherol, though alpha-tocopherol is more commonly studied), has been investigated for its potential role in managing psoriasis due to its antioxidant and anti-inflammatory properties. Several small-scale studies and reviews have explored topical and oral administration of vitamin E in psoriasis patients. Some clinical trials have reported mild to moderate improvements in symptoms such as erythema and scaling when vitamin E was used alone or as an adjunct to other therapies. The proposed mechanisms include reduction of oxidative stress and inhibition of inflammatory cytokines, both of which are implicated in the pathogenesis of psoriasis.

However, the evidence base remains limited. Most studies focus on alpha-tocopherol, and there is a lack of robust, large-scale randomized controlled trials specifically targeting beta-tocopherol or even vitamin E generally. Systematic reviews, including those by the Cochrane Collaboration and other dermatology resources, conclude that while there is some biological plausibility and preliminary evidence, the overall quality and quantity of evidence supporting vitamin E's efficacy in psoriasis are low. Thus, while its use can be considered scientifically explored, recommendations for its routine use in psoriasis management cannot be strongly supported at this time.