Evidence supporting the use of: Vitamin E (mixed tocopherols/tocotrienols)
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, particularly in the forms of mixed tocopherols and tocotrienols, has been investigated for its potential benefits in psoriasis, a chronic inflammatory skin disorder. The rationale for its use is primarily based on its antioxidant and anti-inflammatory properties. Oxidative stress is known to play a role in the pathogenesis of psoriasis, and Vitamin E, as a lipid-soluble antioxidant, may help reduce oxidative damage in skin cells. Some small clinical studies and case reports have evaluated oral or topical Vitamin E supplementation in psoriasis patients, with mixed results. For example, a randomized, double-blind trial found that oral Vitamin E supplementation produced a modest improvement in psoriasis severity, though the effect was less pronounced than standard therapies. Other studies have reported that topical application of Vitamin E may reduce scaling and erythema in mild cases, but evidence is not robust.

Systematic reviews and meta-analyses have concluded that while there is some biological plausibility and limited clinical data supporting a benefit, the quality of evidence is low due to small sample sizes, short study durations, and methodological weaknesses. As a result, Vitamin E is not considered a first-line or well-established therapy for psoriasis, but may be used as an adjunct in some cases. Major dermatological guidelines do not currently recommend Vitamin E as a primary treatment. In summary, there is some scientific rationale and low-level clinical evidence supporting its use, but more rigorous studies are needed to confirm its efficacy.

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