Evidence supporting the use of: Vitamin E (tocopherol not specified)
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (tocopherol, unspecified form) has some scientific evidence supporting its use in the management of psoriasis, though the evidence is limited and not robust. Vitamin E is a fat-soluble antioxidant that can protect cell membranes from oxidative stress, which is believed to play a role in the pathogenesis of psoriasis. Several small clinical studies and case reports have evaluated the efficacy of topical and oral vitamin E in improving psoriasis symptoms. For example, a 1989 double-blind study found that oral vitamin E supplementation led to a modest improvement in psoriasis severity in a subset of patients. Other studies have examined topical formulations in combination with other agents, such as vitamin D analogs, with some benefit noted.

However, large, high-quality randomized controlled trials are lacking, and results across studies are inconsistent. The National Psoriasis Foundation and major dermatological guidelines do not currently recommend vitamin E as a first-line or standalone treatment for psoriasis, though it is sometimes used as an adjunct due to its favorable safety profile. The mechanism by which vitamin E might benefit psoriasis—primarily through reduction of oxidative stress and inflammation—remains plausible but unproven in large-scale clinical settings. In summary, there is limited scientific evidence to support the use of vitamin E for psoriasis, meriting a low-to-moderate evidence score.

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Products containing Vitamin E (tocopherol not specified)

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