Evidence supporting the use of: Vitamin E (tocotrienols)
For the health condition: Psoriasis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (tocotrienols) has been explored for its potential role in supporting or treating psoriasis, primarily due to its antioxidant and anti-inflammatory properties. Several small studies and clinical trials have assessed the effects of vitamin E—especially in combination with other antioxidants—in improving psoriasis symptoms. For example, some research using oral or topical vitamin E (most often in the form of tocopherols, but occasionally tocotrienols) has shown modest improvements in erythema, scaling, and itching. The proposed mechanisms involve the reduction of oxidative stress and inflammation, both of which are implicated in the pathogenesis of psoriasis.

However, the body of evidence specific to tocotrienols is very limited, with most studies focusing on tocopherols or mixed vitamin E preparations. Systematic reviews and meta-analyses generally conclude that while vitamin E may have a minor beneficial effect, the evidence is not robust, and well-designed, large-scale clinical trials are lacking. Major clinical guidelines do not currently recommend vitamin E as a primary or adjunctive therapy for psoriasis due to insufficient evidence.

In summary, there is some limited scientific interest and low-quality evidence suggesting a possible benefit of vitamin E—including tocotrienols—for psoriasis, but it does not have strong scientific validation at this time. Its use is generally considered safe, but it should not replace established therapies.

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Products containing Vitamin E (tocotrienols)

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