Evidence supporting the use of: Lipoic Acid
For the health condition: Radiation Sickness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lipoic acid (also known as alpha-lipoic acid, ALA) has been investigated as a potential supportive agent in radiation sickness due to its antioxidant properties. Scientific studies, primarily in animal models, suggest that lipoic acid can help reduce oxidative stress and cellular damage caused by ionizing radiation. For example, preclinical research in mice and rats exposed to various forms of radiation has shown that lipoic acid administration can decrease radiation-induced lipid peroxidation, protect against DNA damage, and support recovery of certain hematological parameters.

Mechanistically, lipoic acid acts as a free radical scavenger and can regenerate other antioxidants, such as glutathione and vitamins C and E, which are depleted during radiation exposure. Some studies have shown that it may improve survival rates and reduce tissue injury when given before or after radiation exposure.

However, evidence in humans is very limited. There are no large-scale clinical trials demonstrating clear benefits of lipoic acid in the treatment or prevention of radiation sickness in people. Most of the available data is preclinical, and while promising, does not yet provide a strong foundation for routine clinical use. Thus, the evidence is rated as 2 out of 5: there is some preliminary scientific support, but it is not robust or confirmed in human studies.

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