Aloe vera has been used traditionally for centuries to treat various skin conditions, including rashes and hives, due to its soothing and anti-inflammatory properties. Modern scientific research provides moderate support for these traditional uses. Aloe vera gel contains compounds such as polysaccharides, glycoproteins, and acemannan, which have demonstrated anti-inflammatory, immunomodulatory, and wound-healing effects in both in vitro and in vivo studies.

Clinical evidence for aloe vera's effectiveness in treating rashes and hives is limited but promising. A few randomized controlled trials and clinical studies have shown that topical application of aloe vera gel can reduce erythema (redness), itching, and inflammation in cases of atopic dermatitis, psoriasis, and contact dermatitis—conditions with similar inflammatory pathways to rashes and hives. However, direct studies on hives (urticaria) are scarce, and most evidence comes from broader studies on skin irritation and inflammation.

Aloe vera is widely regarded as safe for topical use, with rare cases of allergic reactions. Its cooling and moisturizing properties also provide symptomatic relief for irritated skin. While more rigorous clinical studies are needed to establish its efficacy specifically for hives, the current scientific literature and longstanding traditional use together justify aloe vera’s role as a supportive topical remedy for mild rashes and skin irritation.