Bentonite clay has a long history of traditional use for treating various skin conditions, including rashes and hives. Indigenous cultures and folk medicine practitioners have applied bentonite externally to soothe irritated skin, reduce itching, and promote healing. The clay is believed to work by adsorbing toxins, allergens, and irritants from the skin, thereby reducing inflammation and discomfort. While there are anecdotal reports and small-scale observations suggesting that bentonite can provide relief from rashes and hives, robust clinical research is limited. Scientific studies directly evaluating bentonite's efficacy for rashes and hives are scarce. Some laboratory studies have shown that bentonite has adsorptive properties and can bind certain toxins and bacteria, which may offer a plausible mechanism for its soothing effects. Additionally, bentonite is a common ingredient in calamine lotion and other topical preparations used to relieve itching. However, there are few controlled human trials specifically investigating its effectiveness for rashes or urticaria (hives). Overall, the evidence supporting bentonite’s use for rashes and hives is primarily traditional, with some theoretical scientific basis but limited clinical validation. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should use caution. More rigorous studies are needed to confirm its benefits and clarify its role in dermatological care.