Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bisabolol, a naturally occurring monocyclic sesquiterpene alcohol most commonly derived from German chamomile (Matricaria recutita), is widely used in topical formulations due to its anti-inflammatory, soothing, and skin-repairing properties. Scientific studies indicate that bisabolol exhibits significant anti-inflammatory activity, largely attributed to its ability to inhibit pro-inflammatory cytokines and mediators such as NF-κB and COX-2. Preclinical research, including in vitro and animal studies, has demonstrated that bisabolol can reduce skin irritation, erythema, and inflammation, which are common features of rashes and hives (urticaria). For example, studies have shown bisabolol reduces histamine-induced skin irritation and suppresses markers of allergic response in animal models. Additionally, bisabolol is known for enhancing skin penetration of other active ingredients, which may further improve the efficacy of topical treatments for inflamed skin.

While there is a long-standing traditional use of chamomile extracts in soothing skin conditions, the isolated use of bisabolol is more recent and is now supported by moderate-quality scientific evidence. Clinical trials specifically evaluating bisabolol for rashes and hives in humans are limited, but its inclusion in many dermatological products is based on its well-documented pharmacological effects in preclinical models and its excellent safety profile. Overall, bisabolol’s anti-inflammatory and skin-calming effects justify its use as a supportive ingredient for rashes and hives, though more high-quality human studies would further strengthen the evidence base.

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