Jojoba oil is commonly used as a topical agent to soothe skin irritation, including rashes and, less frequently, hives. The primary scientific basis for its use lies in its composition: jojoba oil is chemically a wax ester similar to human sebum, making it well-tolerated and non-comedogenic. It contains vitamin E and various fatty acids, which may support skin barrier repair and hydration. Some in vitro studies and small human trials suggest jojoba oil has anti-inflammatory properties that could reduce redness and irritation. However, clinical evidence specifically evaluating jojoba oil for the treatment of rashes or hives is limited. Most available studies focus on its general benefits for skin moisturization and wound healing, not directly on dermatologic conditions like urticaria (hives).

While the oil is unlikely to cause irritation in most people, it should not be considered a primary treatment for allergic reactions or serious skin conditions. The evidence level is therefore modest (rated 2/5), with some scientific rationale and limited supporting studies, but lacking robust clinical trials for these specific uses.