Leptadenia (Leptadenia reticulata) has a long history of use in traditional Ayurvedic and Unani medicine systems. It is primarily valued for its galactagogue (milk-promoting) and general tonic properties, but there are references in traditional texts to its use for various skin conditions, including rashes and hives, typically due to its purported anti-inflammatory and soothing effects. Traditional practitioners may use Leptadenia in topical or oral formulations for skin eruptions, although these uses are not as prominent as its application for lactation or reproductive health.

However, scientific validation for Leptadenia's efficacy specifically in treating rashes or hives is minimal. The available modern studies on Leptadenia focus largely on its antioxidant, immunomodulatory, and antimicrobial activities, which theoretically could benefit inflammatory skin conditions, but direct clinical trials or robust preclinical studies targeting rashes or urticaria are lacking. As a result, while its use is justified by tradition, the quality and specificity of evidence supporting Leptadenia for rashes and hives is low, and any claims should be interpreted with caution until more targeted research becomes available.