Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Paederia foetida, also known as skunk vine, is widely used in traditional medicine systems across Asia, including Ayurveda and traditional Chinese medicine. Its use to treat skin conditions such as rashes and hives (urticaria) primarily stems from these traditional practices. Ethnobotanical records indicate that leaves or extracts of Paederia foetida have been applied topically or administered orally to alleviate itching, inflammation, and allergic reactions affecting the skin. These uses are documented in regional folk medicine and some compendiums of medicinal plants, which cite its application for various dermatological complaints, including eczema, boils, and general skin irritation. The purported benefits are generally attributed to the plant’s anti-inflammatory, antimicrobial, and antioxidant properties, as suggested by some preclinical studies. For example, laboratory investigations have demonstrated that extracts of Paederia foetida possess compounds such as iridoid glycosides and flavonoids, which may contribute to reducing inflammation and microbial growth. However, direct scientific studies specifically evaluating its effectiveness for rashes or hives in humans are lacking. Thus, while some in vitro and animal studies support the plant’s general anti-inflammatory effects, there is limited clinical evidence to validate its efficacy for these specific skin conditions. In summary, the use of Paederia foetida for rashes and hives is primarily based on traditional knowledge, with a low-to-moderate level of supporting evidence (rated 2 out of 5), and there is a clear need for controlled clinical studies to confirm its effectiveness for this purpose.

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