Pentatropis capensis, a plant from the Apocynaceae family, has a history of use in traditional medicine in parts of Africa and India. Ethnobotanical surveys and traditional medicinal texts document its application for various skin ailments, including rashes and hives (urticaria). Healers have applied extracts, decoctions, or poultices of the leaves and other plant parts directly to the skin to alleviate irritation, inflammation, and itching associated with such conditions.

The rationale in traditional medicine is likely based on observed soothing effects and possible anti-inflammatory properties, though these mechanisms remain speculative in the absence of direct scientific studies. While some preliminary laboratory research on Pentatropis capensis suggests the presence of bioactive compounds, there is a lack of rigorous clinical or pharmacological studies specifically confirming its efficacy for rashes, hives, or related dermatological conditions. As such, the current evidence is rooted mainly in longstanding traditional use, with only weak or indirect support from preclinical findings.

In summary, the use of Pentatropis capensis for rashes and hives is justified by traditional practices, but there is limited scientific validation. Further studies are needed to confirm the safety and effectiveness of this plant for dermatological applications.