Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Yellow root, commonly referring to Xanthorhiza simplicissima or sometimes to goldenseal (Hydrastis canadensis), has a long history of traditional use in North American herbal medicine, especially among Native American communities. For rashes and hives, yellow root has been applied topically or taken internally in folk remedies, largely due to its perceived anti-inflammatory, antimicrobial, and astringent properties. The active compound most often cited is berberine, an alkaloid known to possess broad antimicrobial activities and some anti-inflammatory effects in laboratory and animal studies. However, there are no robust clinical trials or modern scientific studies that specifically validate the effectiveness of yellow root for treating rashes or hives in humans. Most evidence remains anecdotal or based on historical usage documented in ethnobotanical records. Some herbalists continue to recommend yellow root for skin irritations, often as a wash or poultice, but this is primarily grounded in tradition rather than rigorous scientific validation. Therefore, while there is a plausible basis for its use due to the presence of berberine, the overall level of evidence is low, and those considering its use should exercise caution, particularly due to potential toxicity with excessive use.

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