Evidence supporting the use of: Flavanol (mixture)
For the health condition: Raynaud's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanols, a subclass of flavonoids found in foods such as cocoa, tea, and certain fruits, have been investigated for their vascular benefits, including potential effects in Raynaud's Disease. The rationale is based on their ability to enhance endothelial function and promote vasodilation through increased nitric oxide bioavailability. Several small clinical studies, particularly those using cocoa-derived flavanols, have suggested that these compounds may improve peripheral blood flow and reduce symptoms in individuals with primary Raynaud's phenomenon.

For example, a 2015 pilot study published in Circulation found that acute and chronic consumption of high-flavanol cocoa improved cutaneous blood flow and reduced frequency of Raynaud's attacks in a small group of patients. Another randomized trial reported similar improvements in microvascular function. However, these studies are generally small, short-term, and often focused on surrogate markers (e.g., blood flow measurements) rather than robust clinical outcomes (e.g., reduction in ulceration or long-term symptom control).

There is no substantial traditional use of flavanol mixtures specifically for Raynaud's Disease. The scientific evidence, while promising, remains preliminary and insufficient for strong clinical recommendations. Thus, while the use is justified by emerging scientific data, the overall quality and quantity of evidence is low (rated 2/5), and more large-scale, long-term studies are needed to establish efficacy and safety.

More about Flavanol (mixture)
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Other ingredients used for Raynaud's Disease

ginkgo biloba
omega-3 fatty acids
Danshen

Products containing Flavanol (mixture)

We currently have no products on Vitabase that contain this ingredient.