Evidence supporting the use of: High amylose polysaccharide
For the body system: Rectum

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

High amylose polysaccharide, particularly high amylose maize starch (HAMS), has scientific evidence supporting its beneficial effects on the rectum and lower gastrointestinal tract. High amylose polysaccharides are known as resistant starches, meaning they are not digested in the small intestine and reach the colon intact, where they are fermented by gut microbiota. This fermentation produces short-chain fatty acids (SCFAs), notably butyrate, which serves as the primary energy source for colonocytes (cells lining the colon and rectum) and is associated with anti-inflammatory and protective effects on the mucosal lining.

Several clinical and mechanistic studies have shown that increased intake of resistant starch like HAMS can improve bowel regularity, increase stool bulk, and decrease the risk of colorectal diseases. Butyrate has demonstrated the ability to suppress inflammation, reinforce the gut barrier, and promote mucosal healing, which are relevant to rectal health. Furthermore, human trials have reported that resistant starch consumption can favorably alter the gut microbiota composition and improve symptoms in individuals with bowel disorders, such as constipation and, potentially, inflammatory bowel disease.

While most research has explored the effects on the colon as a whole, the rectum, being the distal part of the large intestine, benefits similarly from these mechanisms. Thus, there is moderate to strong scientific validation for the use of high amylose polysaccharide as supportive to rectal health, primarily through its prebiotic action and production of beneficial SCFAs.

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