Evidence supporting the use of: Hydroxyanthracene
For the body system: Rectum

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Hydroxyanthracenes are a group of naturally occurring compounds found in several medicinal plants, most notably in species such as Aloe, Senna (Senna alexandrina), and Rhamnus (buckthorn). Traditionally, extracts containing hydroxyanthracene derivatives, especially sennosides, have been used as stimulant laxatives to relieve occasional constipation and support bowel movements. Their mechanism of action involves irritation of the colonic mucosa, which increases peristalsis and inhibits water and electrolyte reabsorption, thus softening stool and promoting evacuation.

Historical use of hydroxyanthracene-containing plants for constipation is well documented in various traditional medicine systems, such as Ayurveda and European herbal medicine. The use of senna, for instance, dates back centuries and is recognized in several pharmacopeias. While there is some scientific understanding of their laxative action, much of their use is based on tradition rather than robust clinical evidence. Regulatory agencies such as the European Medicines Agency (EMA) recognize their short-term use for constipation but caution against long-term use due to safety concerns, including potential for electrolyte imbalance and possible carcinogenicity with chronic use. There is little evidence to support uses beyond short-term laxative effects, and their benefit is primarily for constipation rather than broader "rectum body system" support.

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