Evidence supporting the use of: Hydroxyanthracene derivatives
For the body system: Rectum

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Hydroxyanthracene derivatives, such as those found in plants like senna (Senna alexandrina), cascara sagrada, and aloe, have a long history of traditional use for supporting the rectum and lower gastrointestinal tract, primarily as stimulant laxatives. These compounds act on the colon to increase peristalsis and promote bowel movements, which can relieve occasional constipation. Their use is documented in traditional herbal medicine systems, including those of Europe, the Middle East, and Asia. The mechanism of action involves irritation of the colon mucosa, leading to increased fluid secretion and motility.

While there is substantial traditional evidence supporting their use for this purpose, modern scientific evaluation has confirmed their efficacy for short-term relief of constipation. However, the scientific consensus also highlights risks associated with long-term or excessive use, including electrolyte imbalances, dependency, and possible damage to colonic tissues. Regulatory agencies such as the European Medicines Agency (EMA) have acknowledged their traditional use, but recommend strict limits on duration and dose due to safety concerns.

In summary, hydroxyanthracene derivatives are supported by strong traditional evidence and some scientific validation for short-term rectal and bowel support (i.e., as laxatives), but are not recommended for long-term use due to safety risks.

More about hydroxyanthracene derivatives
More about Rectum

Other body systems supported by hydroxyanthracene derivatives

Digestive System
Gastrointestinal Tract
Intestinal System
Large Intestines (Colon)
Rectum

Products containing hydroxyanthracene derivatives

We currently have no products on Vitabase that contain this ingredient.