Evidence supporting the use of: Lactobacillus (unspepcified)
For the body system: Rectum

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus species are commonly used as probiotics and have been investigated for their potential to support rectal and colorectal health, particularly in the prevention and management of conditions such as ulcerative colitis, radiation proctitis, and post-surgical complications. The rectum, being the terminal portion of the large intestine, can benefit from a healthy microbial environment, and Lactobacillus species are known to help maintain or restore the balance of gut microbiota.

Several clinical studies have shown that certain Lactobacillus strains may reduce inflammation, improve mucosal healing, and decrease the recurrence of some symptoms in patients with inflammatory bowel diseases (IBD). For example, randomized controlled trials have demonstrated that multi-strain probiotics including Lactobacillus can be effective in maintaining remission in ulcerative colitis and in reducing symptoms of radiation-induced proctitis. The mechanisms are believed to include modulation of local immune responses, competitive inhibition of pathogenic bacteria, and enhancement of mucosal barrier function.

However, while there is a body of evidence supporting the use of Lactobacillus for general gut health, the evidence specifically targeting the rectum is more limited and tends to be extrapolated from broader studies on the colon or lower gastrointestinal tract. Additionally, the efficacy appears to depend on the specific strain and condition treated. Therefore, while scientific rationale and some clinical data support its use for rectal health, the evidence is moderate and not universally conclusive.

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