Evidence supporting the use of: Polyethylene glycols
For the body system: Rectum

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Polyethylene glycol (PEG) is widely used to support the rectum and lower gastrointestinal tract, primarily as an osmotic laxative. Its use is strongly supported by scientific evidence. PEG works by retaining water in the stool, which increases stool frequency and softens stool consistency, thereby alleviating constipation. Numerous randomized controlled trials and systematic reviews have shown that PEG is effective and safe for treating chronic constipation in both adults and children. It is often considered a first-line therapy for this condition by gastroenterological societies, including the American College of Gastroenterology and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. PEG is also commonly used to prepare the bowel for colonoscopy procedures due to its reliable cleansing effect. Adverse effects are generally mild and may include bloating or abdominal discomfort, but serious side effects are rare. There is no significant evidence of dependence or long-term harm with recommended use. In summary, the use of polyethylene glycol to support rectal and lower GI function is highly validated by modern clinical research and guidelines.

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